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A PRACTICAL OVERVIEW OF QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP
hepatocytes to the novel environment. This involves focal adhesion kinase mediated activation of PI3k/Akt and Raf/Mek/Erk signalling. Further progress in the field of hepatotoxicity will depend on whether [...] Hengstler JG, Godoy P, Bolt HM. The di- lemma of cultivated hepatocytes. Arch Toxicol 2009b;83:101-3.
Hewitt NJ, Lechón MJ, Houston JB, Halli- fax D, Brown HS, Maurel P et al. Primary hepatocytes: current [...] CYP2E1 by quinacrine: molecular modeling investiga- tion and effects on 4-(methyl nitrosamino)- 1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity. Arch Toxicol 2009;83:571- 80.
Magdalan J, Ostrowska …