eldorado.tu-dortmund.de/signposting/describedby/f1024ab8-2fe1-4ebd-a719-6d8b20072056
Entwicklung eines in vitro Systems zur Untersuchung von substanzinduzierten Genexpressionsänderungen
Gsta5, Gsta2, Hsf1, Nqo1, Apex1, Bax, Cdkn1a, Gadd45a, Mt1a, Sds, Mdm2, Myc) and one gene group which is active during cell proliferation (gene group 2: Mcm6, Cdc2, Hdc, 3-Pgdh, Cdc20, Igfbp1, Top2a, Map3k1 [...] measuring additional genes (Bax, Cdkn1, Gsta2, Hsf1, Mdm2 und Nqo1). A concentration dependent effect could also be shown for aflatoxin B1, piperonylbutoxide and 2-nitrofluorene as additional liver-carcinogens [...] the classical collagen monolayer culture, where hepatocytes are cultured on a thin film of collagen, (2) the collagen sandwich culture, where hepatocytes are cultivated between two layers of a collagen gel …