Untersuchung der subzellulären Lokalisation der Rezeptortyrosinkinase HER-3

cancer patients showed a nuclear distribution of HER-3 with little or no HER-3 in cytoplasm. Reverse is also true where patients with cytoplasmic HER-3 had little or none localized to the nucleus. Thus, [...] the nuclear HER-3 expression was analysed. Immunohistochemical analysis revealed high expression of HER-3 in the newly formed tumour tissue leading to the assumption that the nuclear HER-3 expression might [...] signalling of HER-3: the dimerization partner of HER-3 (HER-2) and the ligand (HRGb1). Both factors were investigated to determine if they influence the subcellular distribution of HER-3. A Doxycycline-inducible …

Journal_letzteVersion

! 0 /'?+? * -,.!/ ;6 < /3 !* !/'?+? =?+'(! < 3 , $9* W3 F'9*W3H& (! ' *3' $9* &? >;798>%%;++8))A?# ?/9? + (! 6 0 - / , '! 6- / 3 *< L 2! = / -8! - '( [...] GFCBXH*<?S'(! 3 *< /-='(! L3 /TS'(! L*<? C5 A3 . / 6! = / GS = -2! ! = ? B*31! 67 2 3. 65 -3. " -9* 3. $9* &6P??/ 1===? ? '9*8 ? FS?P?HA)- '(! $'J!I9* ;6 < 6 2 'J! 2! 8= "- [...] +; * 3 2 ) ! 6, -/ = ) ?+< 76 -/ - =! - < !! ?+ 3 ! K ? " ) 3 !/ 2 -!2 " =! ! 9 - = ?+ 6 , !,= , * )- / , - 3 = - ! 7 -F* …

tu-dortmund.de/bitstreams/3168b9db-aea2-43d1-b2b3-7f33c3177a3d/download> ; rel="item" ; type="application/pdf" ; anchor="https://eldorado.tu-dortmund.de/items/5adcea3a-d26c-4421-be6d-7b7138398064" , <https://eldorado [...] ldorado.tu-dortmund.de/bitstreams/3168b9db-aea2-43d1-b2b3-7f33c3177a3d/download" , <https://eldorado.tu-dortmund.de/signposting/linksets/5adcea3a-d26c-4421-be6d-7b7138398064/json> ; rel="linkset" ; ty [...] tps://eldorado.tu-dortmund.de/bitstreams/3168b9db-aea2-43d1-b2b3-7f33c3177a3d/download" , <https://eldorado.tu-dortmund.de/items/5adcea3a-d26c-4421-be6d-7b7138398064> ; rel="collection" ; type="text/html" …

de/bitstreams/01f4aac8-73b3-4b3f-aa9b-7e807e45beb0/download> ; rel="item" ; type="application/pdf" ; anchor="https://eldorado.tu-dortmund.de/items/1cd6991f-2101-4d55-a91f-43532a4636a3" , <https://eldorado. [...] tu-dortmund.de/bitstreams/01f4aac8-73b3-4b3f-aa9b-7e807e45beb0/download" , <https://eldorado.tu-dortmund.de/signposting/linksets/1cd6991f-2101-4d55-a91f-43532a4636a3/json> ; rel="linkset" ; type="applic [...] orado.tu-dortmund.de/bitstreams/01f4aac8-73b3-4b3f-aa9b-7e807e45beb0/download" , <https://eldorado.tu-dortmund.de/items/1cd6991f-2101-4d55-a91f-43532a4636a3> ; rel="collection" ; type="text/html" ; an …

778eeabc-ac83-4c11-933c-6313af2c3da3/download> ; rel="item" ; type="application/pdf" ; anchor="https://eldorado.tu-dortmund.de/items/65a2587c-e4ff-437f-bac7-8979d721fb3f" , <https://eldorado.tu-dortmund [...] .de/bitstreams/778eeabc-ac83-4c11-933c-6313af2c3da3/download" , <https://eldorado.tu-dortmund.de/signposting/linksets/65a2587c-e4ff-437f-bac7-8979d721fb3f/json> ; rel="linkset" ; type="application/lin [...] tu-dortmund.de/bitstreams/778eeabc-ac83-4c11-933c-6313af2c3da3/download" , <https://eldorado.tu-dortmund.de/items/65a2587c-e4ff-437f-bac7-8979d721fb3f> ; rel="collection" ; type="text/html" ; anchor="http …

do.tu-dortmund.de/bitstreams/8bc936f3-3f7c-43ec-b0fa-585dba335825/download> ; rel="item" ; type="application/pdf" ; anchor="https://eldorado.tu-dortmund.de/items/3e15a537-84b7-459c-b880-6b26c9008be2" [...] anchor="https://eldorado.tu-dortmund.de/bitstreams/8bc936f3-3f7c-43ec-b0fa-585dba335825/download" , <https://eldorado.tu-dortmund.de/signposting/linksets/3e15a537-84b7-459c-b880-6b26c9008be2/json> ; rel="linkset" [...] ; anchor="https://eldorado.tu-dortmund.de/bitstreams/8bc936f3-3f7c-43ec-b0fa-585dba335825/download" , <https://eldorado.tu-dortmund.de/items/3e15a537-84b7-459c-b880-6b26c9008be2> ; rel="collection" ; t …

de/bitstreams/9a7a3ad1-24cc-4e65-91d8-07eaba2b8a3c/download> ; rel="item" ; type="application/pdf" ; anchor="https://eldorado.tu-dortmund.de/items/3084ae06-1da1-47de-9510-ce832c1b98c3" , <https://eldorado [...] o.tu-dortmund.de/bitstreams/9a7a3ad1-24cc-4e65-91d8-07eaba2b8a3c/download" , <https://eldorado.tu-dortmund.de/signposting/linksets/3084ae06-1da1-47de-9510-ce832c1b98c3/json> ; rel="linkset" ; type="ap [...] /eldorado.tu-dortmund.de/bitstreams/9a7a3ad1-24cc-4e65-91d8-07eaba2b8a3c/download" , <https://eldorado.tu-dortmund.de/items/3084ae06-1da1-47de-9510-ce832c1b98c3> ; rel="collection" ; type="text/html" ; …

tu-dortmund.de/bitstreams/7382ff48-14e3-419a-8129-a60c9ddb3f36/download> ; rel="item" ; type="application/pdf" ; anchor="https://eldorado.tu-dortmund.de/items/aec71ee3-0317-40bc-abc6-ed12ba9565e8" , <htt [...] ://eldorado.tu-dortmund.de/bitstreams/7382ff48-14e3-419a-8129-a60c9ddb3f36/download" , <https://eldorado.tu-dortmund.de/signposting/linksets/aec71ee3-0317-40bc-abc6-ed12ba9565e8/json> ; rel="linkset" ; [...] anchor="https://eldorado.tu-dortmund.de/bitstreams/7382ff48-14e3-419a-8129-a60c9ddb3f36/download" , <https://eldorado.tu-dortmund.de/items/aec71ee3-0317-40bc-abc6-ed12ba9565e8> ; rel="collection" ; type="text/html" …