eldorado.tu-dortmund.de/items/f1024ab8-2fe1-4ebd-a719-6d8b20072056
Entwicklung eines in vitro Systems zur Untersuchung von substanzinduzierten Genexpressionsänderungen
group which is active during cell proliferation (gene group 2: Mcm6, Cdc2, Hdc, 3-Pgdh, Cdc20, Igfbp1, Top2a, Map3k1, Atf3). The in vitro experiments were performed related to this thesis. The results from [...] the gene expression of four markergenes (Abat, Gsk3b, Myd116 and Sult1a1) was measured. These genes were already known as characteristically up- (Gsk3b, Myd116) and downregulated (Abat, Sult1a1) under [...] collagen sandwich culture, where hepatocytes are cultivated between two layers of a collagen gel and (3) Matrigel®-culture, a commercially available smooth extracellular matrix in which the hepatocytes are …