CONCEPT:

Soc. 1993;115:10466-7 Lacourciere GM, Armstrong RN. Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes. Chem. Res. Toxicol. 1994;7:121-4 Laughlin LT, [...] intermediate. J. Am. Chem. Soc. 1996;118:9436-7 von Mach MA. Primary biliary cirrhosis in classmates: coincidence or enigmatic environmental influence? EXCLI J 2002;1:1-7 Zou J-Y, Hallberg BM, Bergfors T, Oesch [...] of tons per year. In human, most of the styrene is metabolically oxidized to the genotoxic styrene 7,8-oxide (Jenkins Sumner et al., 1994).This intermediate is detoxified almost exclusively by EH, with …