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Enhanced interleukin-10 signaling with 14-member macrolides in lipopolysaccharide-stimulated macroph

IL-10 receptor, phosphorylated (p) STAT-3, and SOCS-3 were determined by RT-PCR, ELISA and immunoblotting. We observed increased levels of IL-10, p-STAT-3 and SOCS-3 in the treated cells. In addition, while [...] enhancement of the IL-10/STAT-3/SOCS-3 pathway. en EXCLI Journal ; Vol. 7, 2008 clarithromycin erythromycin immunomodulatory effects interleukin-10 macrophage SOCS-3 STAT3 610 Enhanced interleukin-10 signaling [...] activates sig-nal transducer and activator of transcription (STAT)-3, and subsequently induces the suppres-sor of cytokine signaling-3 (SOCS-3), resulting in the resolution of inflammatory response in macrophages …